Metabolic abnormalities of mitochondrial redox potential in postburn multiple system organ failure

• Published in: Burns Vol. 18; no. 4; pp. 283 - 286
• Main Authors: Dong, Y-L., Sheng, C-Y., Herndon, D.N., Waymack, J.P.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.08.1992; Elsevier Science
• Subjects: Acetoacetates - blood; Amino Acids, Branched-Chain - blood; Biological and medical sciences; Burns; Burns - blood; Burns - metabolism; Female; Humans; Hydroxybutyrates - blood; Ketone Bodies - metabolism; Liver - metabolism; Male; Medical sciences; Mitochondria - metabolism; Multiple Organ Failure - metabolism; Oxidation-Reduction; Traumas. Diseases due to physical agents; Ketone body; Human; Skin disease; Biochemical analysis; Pathophysiology; Multiple organ failure; Exploration; Trauma; Blood plasma; Burn; Mitochondria; Metabolic disorder; Aminoacid; Complication; Redox potential
• ISSN: 0305-4179; 1879-1409
• DOI: 10.1016/0305-4179(92)90148-N

Forty-five burn patients underwent sequential assays for plasma acetoacetate and beta-hydroxybutyrate concentrations as well as plasma amino acid levels. Those patients who went on to develop multiple system organ failure were noted to have a decrease in their acetoacetate concentration with time, whereas there was no change in those patients who failed to develop multiple system organ failure. The plasma concentration of beta-hydroxybutyrate was not altered by multiple system organ failure. In addition, the plasma acetoacetate/beta-hydroxybutyrate ratio was found to be directly related to the plasma concentration of branched chain amino acids and inversely related to the concentration of aromatic amino acids.