Enhanced immune activation linked to endotoxemia in HIV-1 seronegative MSM

This study assessed cellular and soluble markers of immune activation in HIV-1 seronegative MSM. MSM immune profiles were characterized by an increased expression of CD57 on T cells and endotoxemia. Endotoxin presence was linked to recent high-risk exposure and associated with elevated cytokine leve...

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Bibliographic Details
Published inAIDS (London) Vol. 28; no. 14; pp. 2162 - 2166
Main Authors Palmer, Christine D, Tomassilli, Julia, Sirignano, Michael, Romero-Tejeda, Marisol, Arnold, Kelly B, Che, Denise, Lauffenburger, Douglas A, Jost, Stephanie, Allen, Todd, Mayer, Kenneth H, Altfeld, Marcus
Format Journal Article
LanguageEnglish
Published England 10.09.2014
Subjects
AIDS/HIV
CD4-Positive T-Lymphocytes - immunology
CD57 Antigens - immunology
CD8-Positive T-Lymphocytes - immunology
Endotoxemia - immunology
HIV Seronegativity - immunology
HIV-1 - immunology
Homosexuality, Male - statistics & numerical data
Human immunodeficiency virus 1
Humans
Immunity, Cellular - immunology
Lentivirus
Lymphocyte Activation - immunology
Male
T-Lymphocytes, Cytotoxic - immunology
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Summary:This study assessed cellular and soluble markers of immune activation in HIV-1 seronegative MSM. MSM immune profiles were characterized by an increased expression of CD57 on T cells and endotoxemia. Endotoxin presence was linked to recent high-risk exposure and associated with elevated cytokine levels and decreased CD4+/CD8+ T cell ratios. Taken together, these data show elevated levels of inflammation linked to periods of endotoxemia resulting in a significantly different immune phenotype in a subset of MSM at a high risk of HIV-1 acquisition.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0269-9370
1473-5571
DOI:10.1097/QAD.0000000000000386