Photosensitizer-incorporated G-quadruplex DNA-functionalized magnetofluorescent nanoparticles for targeted magnetic resonance/fluorescence multimodal imaging and subsequent photodynamic therapy of cancer

A smart heteronanostructure has been constructed for targeted photodynamic therapy and magnetic fluorescent imaging of cancer cells using photosensitizer-incorporated G-quadruplex DNA functionalized magnetic nanoparticles.

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 48; no. 52; pp. 6556 - 6558
Main Authors Yin, Meili, Li, Zhenhua, Liu, Zhen, Ren, Jinsong, Yang, Xinjian, Qu, Xiaogang
Format Journal Article
LanguageEnglish
Published England 01.01.2012
Subjects
Animals
Breast Neoplasms - diagnosis
Breast Neoplasms - therapy
Cancer
Cell Line, Tumor
Female
Fluorescent Dyes - chemistry
Fluorescent Dyes - therapeutic use
G-Quadruplexes
Humans
Magnetic Resonance Imaging
Magnets - chemistry
Mice
Nanoparticles - chemistry
Nanoparticles - therapeutic use
Nanoparticles - ultrastructure
NIH 3T3 Cells
Photochemotherapy - methods
Photosensitizing Agents - chemistry
Photosensitizing Agents - therapeutic use
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Summary:A smart heteronanostructure has been constructed for targeted photodynamic therapy and magnetic fluorescent imaging of cancer cells using photosensitizer-incorporated G-quadruplex DNA functionalized magnetic nanoparticles.
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ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc32129g