Variables affecting nicotine metabolism

• Published in: Pharmacology & therapeutics (Oxford) Vol. 60; no. 3; pp. 461 - 500
• Main Authors: Seaton, M.J., Vesell, E.S.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.01.1993; Elsevier
• Subjects: Aging - metabolism; Animals; Biological and medical sciences; Cimetidine - pharmacology; Dietary Proteins - pharmacology; Drug Interactions; Ethanol - pharmacology; Female; Genetic Variation; host factor; Humans; Medical sciences; Nicotine - administration & dosage; Nicotine - metabolism; Nicotine - pharmacokinetics; Pregnancy - metabolism; Smoking; Species Specificity; Tobacco, tobacco smoking; Toxicology; variables; MS, mass spectrometry; variables; host factor; Nicotine metabolism; CNX, cotinine N-oxidel ETS, environmental tobacco smoke; FMO, flavin-containing monooxygenase; RIA, radioimmunoassay; NIM, nicotine iminium ion; GC, gas chromatography; NNX, nicotine-1′- N-oxide; UDPGT, uridine diphospho-glucuronsyl transferase; Human; Toxicokinetics; Tobacco; Review; Intraspecific comparison; Metabolism; Nicotine
• ISSN: 0163-7258; 1879-016X
• DOI: 10.1016/0163-7258(93)90032-9

Nicotine metabolism is exceedingly sensitive to perturbation by numerous host factors. To reduce the large variations and discrepancies in the literature pertaining to nicotine metabolism, investigators in future studies need to recognize and better control these host factors. Recent advances in the understanding of nicotine metabolism have suggested new approaches to elucidating underlying mechanisms of certain toxic effects associated with cigarette smoking.