Synthesis and Antimicrobial Activity of Novel Polycyclic Thienopyridazine Derivatives

A series of novel thienopyridazine derivatives has been synthesized using 9-aminodibenzo[ f , h ]thieno[2,3- c ]cinnoline-8-carbonitrile as starting material. The target products exhibit promising antibacterial and antifungal properties against bacterial strains E. coli , S. aureus , B. subtilis , a...

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Bibliographic Details
Published inChemistry of heterocyclic compounds (New York, N.Y. 1965) Vol. 55; no. 8; pp. 773 - 778
Main Authors Fayed, Ahmed A., Yousif, Mahmoud N. M., Abdelgawad, Taha T., Amr, Abd El-Galil E., Yousif, Nabil M., Gad, Farouk A.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.08.2019
Springer Nature
Springer
Springer Nature B.V
Subjects
Antimicrobial agents
Bacterial pneumonia
Chemistry
Chemistry and Materials Science
Chemistry, Organic
Derivatives
E coli
Escherichia coli
Fungicides
Microorganisms
Organic Chemistry
Pharmacy
Physical Sciences
Pneumonia
Science & Technology
Tetracycline
Tetracyclines
pyridothienocinnoline
thienopyridazine
thienocinnoline
pyrimidothienocinnoline
triazolopyrimidothienocinnoline
antimicrobial agent
thiazinothienocinnoline
thiazolopyrimidothienocinnoline
DESIGN
PYRIDINE
ANTICONVULSANT
INHIBITORS
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Summary:A series of novel thienopyridazine derivatives has been synthesized using 9-aminodibenzo[ f , h ]thieno[2,3- c ]cinnoline-8-carbonitrile as starting material. The target products exhibit promising antibacterial and antifungal properties against bacterial strains E. coli , S. aureus , B. subtilis , and K. pneumoniae and fungal strains A. fumigatus and C. albicans . The highest antimicrobial activity against all tested microorganisms demonstrate pyridothienocinnoline derivatives.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-019-02534-1