Further evidence for an association between schizophrenia and the HLA DQB1 gene locus

• Published in: Schizophrenia research Vol. 18; no. 1; pp. 43 - 49
• Main Authors: Nimgaonkar, V.L., Rudert, W.A., Zhang, X.R., Tsoi, W.-F., Trucco, M., Saha, N.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.12.1995; Elsevier Science
• Subjects: Adult; Adult and adolescent clinical studies; Alleles; Association; Biological and medical sciences; Case-Control Studies; China - ethnology; Chromosome Mapping; Gene Frequency - genetics; Genetic Markers; Genetics; HLA; HLA DQB1; HLA-DQ Antigens - genetics; HLA-DQ beta-Chains; Humans; Male; Medical sciences; Middle Aged; Models, Genetic; Odds Ratio; Polymorphism, Genetic - genetics; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Schizophrenia; Schizophrenia - diagnosis; Schizophrenia - ethnology; Schizophrenia - genetics; Schizophrenic Psychology; Singapore; China; Singapore; Schizophrenia; Genetics; HLA DQB1; Association; HLA; Human; HLA-DQ-Locus; Psychosis; HLA-System; Genetic inheritance; Polymorphism
• ISSN: 0920-9964; 1573-2509
• DOI: 10.1016/0920-9964(95)00023-2

A case-control study was conducted in Singapore, in order to examine a proposed association between schizophrenia and the HLA DQB1 gene locus. The probands were male inpatients of Chinese ethnicity with schizophrenia (ICD-10 criteria, n = 102) and the controls were adults matched for gender and ethnicity (n = 111). Polymorphisms of the HLA DQB1 gene were examined using molecular typing by reverse dot-blotting (MTRB), a novel PCR based method. Among the patients, a positive association with HLA DQB1 ∗0303 (odds ratio 4.46, C.I. 1.63, 12.17), as well as a negative association with HLA DQB1 ∗0602 (odds ratio 0.22, C.I. 0.18, 0.83) was detected.