Skin disorders and vitamin A metabolism disturbances in chronic dialysis patients: the role of zinc, retinol-binding protein, retinol and retinoic acid

• Published in: Clinica chimica acta Vol. 137; no. 3; pp. 283 - 289
• Main Authors: Delacoux, E., Evstigneeff, Th, Leclercq, M., Rettori, M.C., Delons, S., Naret, C., Blanchet-Bardon, C.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 13.03.1984; Elsevier
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Emergency and intensive care: renal failure. Dialysis management; Hemodialysis patient; Humans; Hypervitaminosis A; Intensive care medicine; Keratosis - blood; Keratosis - etiology; Medical sciences; Renal Dialysis - adverse effects; Retinoic acid; Retinol; Retinol-binding protein; Retinol-Binding Proteins - blood; Retinol-Binding Proteins, Plasma; Skin - pathology; Skin disease; Skin Diseases - blood; Skin Diseases - etiology; Tretinoin - blood; Vitamin A - blood; Zinc; Zinc - blood; Skin disease; Retinoic acid; Hemodialysis patient; Zinc; Retinol-binding protein; Retinol; Human; Extrarenal dialysis; Metabolic disorder; Urinary system disease; Hemodialysis; Vitamin; Resuscitation
• ISSN: 0009-8981; 1873-3492
• DOI: 10.1016/0009-8981(84)90116-5

The authors have studied — in the plasma — the changes of zinc, retinol binding protein (RBP), retinol and retinoic acid with reference to the dermatological status of fifty chronically haemodialysed renal insufficiency patients divided into four subgroups (normal skin, dry skin, dry skin with keratosis, and only keratosis). The results of these groups were compared to those of thirty healthy subjects. The values of these variables do not show any significant difference in function of the dermatological subgroups; but, despite the considerable rise in the retinol binding protein and retinol levels in comparison with the controls (haemodialysis patients: RBP = 11.77 ± 2.83 μmol·1 −1, retinol = 7 ± 2.57 μmol·1 −1; controls: RBP = 2.76 ± 0.62 μmol·1 −1, retinol = 2.16 ± 0.53 μmol·1 −1) the electromicroscopic examination of skin biopsy samples from some of the patients did not reveal any sign of hypervitaminosis A in the lesions.