The effect of age, sex, alcohol consumption and cigarette smoking on serum concentrations of lipids and apolipoproteins in Zimbabwean blacks

• Published in: Atherosclerosis Vol. 61; no. 2; pp. 149 - 154
• Main Author: Gomo, Zvenyika A.R.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ireland Ltd 01.08.1986; Elsevier
• Subjects: Adult; African Americans; African Continental Ancestry Group; Age; Age Factors; Aged; Alcohol consumption; Alcohol Drinking; Apolipoproteins; Apolipoproteins - blood; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blacks in Zimbabwe; Blood and lymphatic vessels; Cardiology. Vascular system; Cholesterol, HDL - blood; Cigarette smoking; Female; Humans; Lipids; Lipids - blood; Male; Medical sciences; Middle Aged; Sex; Sex Factors; Smoking; Triglycerides - blood; Zimbabwe; Zimbabwe; Alcohol consumption; Sex; Lipids; Apolipoproteins; Cigarette smoking; Age; Blacks in Zimbabwe; Consumption; Human; Alcoholic beverage; Atherosclerosis; Tobacco smoking; Cardiovascular disease; Serum; Blood
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/0021-9150(86)90075-4

Serum concentrations of total cholesterol, HDL cholesterol, triglycerides and apolipoproteins A-I and B were studied in black subjects with no known risk factor for coronary heart disease and in subjects with a single risk factor. The concentrations of lipids and apolipoproteins were sex-dependent. HDL cholesterol and apolipoprotein A-I were age-dependent in females ( P < 0.05 and P < 0.01, respectively). There was a dose-related association between alcohol consumption and serum concentrations of triglycerides, HDL cholesterol, apolipoproteins A-I and B in males ( P < 0.001 and P < 0.002, respectively in the heavy drinkers). The effects of cigarette smoking on the concentrations of serum lipids and apolipoproteins appear to be prominent in the heavy smoking subjects ( P < 0.001 and P < 0.001, respectively). This work suggests that HDL cholesterol and apolipoprotein A-I may discriminate black subjects at risk of developing atherosclerosis.