Effects of amycenone on serum levels of tumor necrosis factor-α, interleukin-10, and depression-like behavior in mice after lipopolysaccharide administration

• Published in: Pharmacology, biochemistry and behavior Vol. 136; pp. 7 - 12
• Main Authors: Yao, Wei, Zhang, Ji-chun, Dong, Chao, Zhuang, Cun, Hirota, Susumu, Inanaga, Kazutoyo, Hashimoto, Kenji
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2015
• Subjects: Amycenone; Animals; Anti-inflammatory activity; Antidepressive Agents - pharmacology; Antidepressive Agents - therapeutic use; Behavior, Animal - drug effects; Cytokine; Depression; Depression - blood; Depression - chemically induced; Depression - drug therapy; Dose-Response Relationship, Drug; Hericium erinaceum; Interleukin-10 - blood; Lipopolysaccharides; Male; Mice; Paroxetine - pharmacology; Paroxetine - therapeutic use; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Tumor Necrosis Factor-alpha - blood; Depression; Anti-inflammatory activity; Amycenone; Hericium erinaceum; Cytokine
• ISSN: 0091-3057; 1873-5177
• DOI: 10.1016/j.pbb.2015.06.012

Accumulating evidence suggests that inflammation plays a role in the pathophysiology of depression and that anti-inflammatory substances have antidepressant effects. Amycenone is obtained from extracts of the Yamabushitake (Hericium erinaceum). The purpose of this study is to examine whether amycenone shows anti-inflammatory and antidepressant effects in an inflammation-induced mouse model of depression. First, we examined the effects of amycenone on the serum levels of the pro-inflammatory cytokine, tumor necrosis factor-α (TNF-α), and the anti-inflammatory cytokine, interleukin-10 (IL-10), after intraperitoneal administration of the bacterial endotoxin lipopolysaccharide (LPS). Oral administration of amycenone (50, 100, or 200mg/kg) markedly blocked an increase in the serum TNF-α levels after a single administration of LPS (0.5mg/kg). Furthermore, amycenone (200mg/kg) markedly increased the serum IL-10 levels by a single administration of LPS (0.5mg/kg). Next, we examined the effects of amycenone on depression-like behaviors in the tail-suspension test (TST) and forced swimming test (FST). Pretreatment with amycenone (200mg/kg) significantly attenuated LPS (0.5mg/kg)-induced increase of the immobility time by the TST and FST, indicating antidepressant effects of amycenone. In addition, oral administration of paroxetine (30mg/kg) showed anti-inflammatory and antidepressant effects in the same model. These findings suggest that amycenone has antidepressant effects in LPS-induced inflammation model of depression. Therefore, amycenone could represent a potential supplement to prevent inflammation-related depression. •Amycenone is obtained from extracts of the Hericium erinaceum.•Amycenone has an anti-inflammatory effect on lipopolysaccharide-induced model.•Amycenone has an antidepressant effect in inflammation model of depression.•Amycenone would be a supplement to prevent inflammation-induced depression.