Thromboxane and prostacyclin generation by human umbilical veins after thrombin

Prostacyclin (PGI 2) and Thromboxane B 2 (TxB 2) production induced by thrombin in human umbilical veins (HUV) was studied. Successive stimulations of HUV segments were performed with and without restoration of arachidonic acid (AA). Thrombin consistently stimulated the production of both substances...

Full description

Saved in:
Bibliographic Details
Published inProstaglandins Vol. 42; no. 6; pp. 571 - 578
Main Authors Torres-Duarte, A., Amezcua, J.L.
Format Journal Article
LanguageEnglish
Published Stoneham, MA Elsevier Inc 01.12.1991
Butterworth-Heinemann
Subjects
Arachidonic Acid - pharmacology
Biological and medical sciences
Blood vessels and receptors
Epoprostenol - biosynthesis
Fundamental and applied biological sciences. Psychology
Humans
Thrombin - pharmacology
Thromboxane B2 - biosynthesis
Umbilical Veins - drug effects
Umbilical Veins - metabolism
Vertebrates: cardiovascular system
Human
Prostaglandin I2
Enzyme
Arachidonic acid derivatives
Blood vessel
Thrombin
Biosynthesis
Circulatory system
Thromboxane
Umbilical vein
Online AccessGet full text

Cover

More Information
Summary:Prostacyclin (PGI 2) and Thromboxane B 2 (TxB 2) production induced by thrombin in human umbilical veins (HUV) was studied. Successive stimulations of HUV segments were performed with and without restoration of arachidonic acid (AA). Thrombin consistently stimulated the production of both substances. The magnitude of the increment declined with progressive stimuli. The addition of exogenous AA could restore the prodcution of TXB 2 but not that of PGI 2. These results suggests that sustained stimulation of AA release may lead to an imbalance in the TXA 2/PGI 2 ratio perphaps through an effect of unkown products of AA oxidation on PGI 2 synthase.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0090-6980
DOI:10.1016/0090-6980(91)90018-B