p53 tumor suppressor gene protein expression in cervical cancer: relationship to prognosis

• Published in: European journal of obstetrics & gynecology and reproductive biology Vol. 63; no. 1; pp. 55 - 59
• Main Authors: Bremer, Gerard L., Tieboschb, Anton T.M.G., van der Putten, Hans W.H.M., de Haan, Jelte, Arends, Jan-Willem
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.11.1995; Elsevier
• Subjects: Antibodies, Monoclonal; Biological and medical sciences; Cervical Cancer; Female; Gene Expression; Genes, p53; Genital system. Mammary gland; Humans; Immunohistochemistry; Investigative techniques, diagnostic techniques (general aspects); Lymph Nodes - pathology; Lymphatic Metastasis; Medical sciences; Mutation; Neoplasm Staging; p53; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Prognosis; Survival; Survival Rate; Tumor suppressor gene; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - mortality; Uterine Cervical Neoplasms - pathology; Immunohistochemistry; Cervical Cancer; Survival; p53; Tumor suppressor gene; Human; Carcinoma; Prognosis; Malignant tumor; Uterine cervix; Female genital diseases; p53 gene; Pathology; Gene; Female; Mutation; Uterine cervix diseases
• ISSN: 0301-2115; 1872-7654
• DOI: 10.1016/0301-2115(95)02225-V

Objective: Mutation of the p53 gene can be found in several human tumors. We tested the hypothesis whether overexpression of p53 protein is a parameter of more aggressive disease in patients with cervical cancer. Study design: In this study, we describe the effects of p53 overexpression in 156 patients with cervical cancer (Figo stage IB-IV) by assessing expression patterns of the p53 gene product using a monoclonal anti-p53 antibody (DO7). Results: Overexpression of p53 tumor suppressor gene protein was observed in 30.2% of the tumors, low expression in 30.7% and 39.1% of the tumors showed no p53 immunoreactivity. With increase in stage, p53 overexpression raised from 20.1% in stage IB to 60% in stage IV. A significant correlation between p53 overexpression and disease-free survival of patients was observed, however, after stratification for stage, this effect disappeared. Conclusions: The p53 mutation expressed as p53 tumor suppressor gene protein overexpression is a late event in cervical cancer genesis and does not appear to be of prognostic significance in cervical cancer.