The diffuse distribution of Nav1.2 on mid-axonal regions is a marker for unmyelinated fibers in the central nervous system

• Published in: Neuroscience research Vol. 177; pp. 145 - 150
• Main Authors: Yamano, Risa, Miyazaki, Haruko, Nukina, Nobuyuki
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.04.2022
• Subjects: Axons - physiology; Central Nervous System; Corpus callosum; Immunohistochemistry; Mid-axon; Nav 1.2; NAV1.2 Voltage-Gated Sodium Channel; Stria terminalis; Unmyelinated fibers; Voltage-Gated Sodium Channels; Nav 1.2; Stria terminalis; Corpus callosum; Mid-axon; Central nervous system; Unmyelinated fibers
• ISSN: 0168-0102; 1872-8111
• DOI: 10.1016/j.neures.2021.11.005

•The immunoelectron microscopy revealed Nav1.2 locations in the unmyelinated fibers.•Nav1.2 is a useful marker for unmyelinated fibers in the central nervous system.•Unmyelinated fibers exist in the corpus callosum and the stria terminalis. Unmyelinated fibers in the central nervous system are known to exist in hippocampal mossy fibers, cerebellar parallel fibers and striatal projection fibers. Previously, we and others reported diffuse distribution of Nav1.2, a voltage-gated sodium channel α-subunit encoded by the SCN2A gene, on unmyelinated striatal projection fibers. Mutations in the SCN2A gene are associated with epilepsies and autism. In this study, we investigated the distribution of Nav1.2 on the unmyelinated fibers in the corpus callosum and stria terminalis by immunohistochemistry and immunoelectron microscopy analysis, suggesting that diffuse localization of Nav1.2 on mid-axonal regions can be a useful marker for unmyelinated fibers.