Lymphvascular space involvement—A prognostic indicator in endometrial adenocarcinoma

• Published in: Gynecologic oncology Vol. 42; no. 2; pp. 142 - 145
• Main Authors: Gal, David, Recio, Fernando O., Zamurovic, Dragoslava, Tancer, M.Leon
• Format: Journal Article Conference Proceeding
• Language: English
• Published: San Diego, CA Elsevier Inc 01.08.1991; Elsevier
• Subjects: Adenocarcinoma - mortality; Adenocarcinoma - pathology; Biological and medical sciences; Blood Vessels - pathology; Female; Female genital diseases; Gynecology. Andrology. Obstetrics; Humans; Lymphatic Metastasis; Lymphatic System - pathology; Medical sciences; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Survival Rate; Tumors; Uterine Neoplasms - mortality; Uterine Neoplasms - pathology; Adenocarcinoma; Human; Clinical stage; Prognosis; Uterus; Female; Early; Metastasis; Malignant tumor; Endometrium; Invasion; Female genital diseases
• ISSN: 0090-8258; 1095-6859
• DOI: 10.1016/0090-8258(91)90334-2

The present study evaluates the effects of various prognostic indicators on survival of patients with clinical Stage I endometrial carcinoma. Ninety-three patients who were treated for clinical Stage I endometrial adenocarcinoma at Maimonides Medical Center from October 1979 to October 1987 had sufficient surgical-pathological information for retrospective surgical staging according to the new FIGO classification. Histology was reviewed. A new grade and surgical stage was assigned to each patient in accordance with the recent FIGO guidelines for surgical staging of corpus cancer. Poor prognostic indicators, namely, tumor grade, depth of myometrial invasion, peritoneal cytology, lymph node metastases, and lymphvascular space (LVS) involvement, were correlated with 5-year survival rates. Survival rates were calculated by the life table method. Depth of myometrial invasion, lymph node involvement, and peritoneal cytology had significant statistical correlation with poor survival. Positive finding of each of the prognostic indicators, including LVS involvement, was significantly associated with poor survival (all P < 0.001). The value of these prognostic indicators in early endometrial carcinoma is discussed.