Antibody Response to Omicron BA.4–BA.5 Bivalent Booster

Boosting Vaccination with BA.4–BA.5 SequencesIn a small study, a bivalent mRNA vaccine targeting omicron BA.4–BA.5 sublineages resulted in similar neutralization of other SARS-CoV-2 variants as a fourth dose of a monovalent mRNA vaccine.

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Published in	The New England journal of medicine Vol. 388; no. 6; pp. 567 - 569
Main Authors	Wang, Qian, Bowen, Anthony, Valdez, Riccardo, Gherasim, Carmen, Gordon, Aubree, Liu, Lihong, Ho, David D.
Format	Journal Article
Language	English
Published	United States Massachusetts Medical Society 09.02.2023
Subjects	Antibodies Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Antibody Formation - immunology Antibody response Coronavirus COVID-19 - immunology COVID-19 - prevention & control COVID-19 - virology Humans Immunization Infections Infectious Disease mRNA mRNA vaccines Severe acute respiratory syndrome coronavirus 2 Vaccines Vaccines, Combined - immunology Vaccines, Combined - therapeutic use Viral Infections
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Abstract	Boosting Vaccination with BA.4–BA.5 SequencesIn a small study, a bivalent mRNA vaccine targeting omicron BA.4–BA.5 sublineages resulted in similar neutralization of other SARS-CoV-2 variants as a fourth dose of a monovalent mRNA vaccine.
AbstractList	Boosting Vaccination with BA.4–BA.5 SequencesIn a small study, a bivalent mRNA vaccine targeting omicron BA.4–BA.5 sublineages resulted in similar neutralization of other SARS-CoV-2 variants as a fourth dose of a monovalent mRNA vaccine. In a small study, a bivalent mRNA vaccine targeting omicron BA.4–BA.5 sublineages resulted in similar neutralization of other SARS-CoV-2 variants as a fourth dose of a monovalent mRNA vaccine.
Author	Gherasim, Carmen Bowen, Anthony Liu, Lihong Gordon, Aubree Wang, Qian Ho, David D. Valdez, Riccardo
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Cites_doi	10.1038/s41591-022-02092-8 10.1038/s41586-022-05053-w 10.1056/NEJMoa2208343 10.1016/j.it.2021.09.001
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References_xml	– year: 2022 ident: r2 article-title: Coronavirus (COVID-19) update: FDA authorizes Moderna, Pfizer-BioNTech bivalent COVID-19 vaccines for use as a booster dose ;(https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-moderna-pfizer-biontech-bivalent-covid-19-vaccines-use) – volume: 608 start-page: 603 year: 2022 end-page: 608 ident: r1 article-title: Antibody evasion by SARS-CoV-2 omicron subvariants BA.2.12.1, BA.4 and BA.5. publication-title: Nature – volume: 387 start-page: 1279 year: 2022 end-page: 1291 ident: r3 article-title: A bivalent omicron-containing booster vaccine against Covid-19. publication-title: N Engl J Med – volume: 42 start-page: 956 year: 2021 end-page: 959 ident: r5 article-title: Immune imprinting and SARS-CoV-2 vaccine design. publication-title: Trends Immunol – year: 2022 ident: r4 article-title: Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 omicron variant in mice. publication-title: Nat Med ;(Epub ahead of print) – ident: e_1_3_4_3_2 – ident: e_1_3_4_5_2 doi: 10.1038/s41591-022-02092-8 – ident: e_1_3_4_2_2 doi: 10.1038/s41586-022-05053-w – ident: e_1_3_4_4_2 doi: 10.1056/NEJMoa2208343 – ident: e_1_3_4_6_2 doi: 10.1016/j.it.2021.09.001
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Snippet	In a small study, a bivalent mRNA vaccine targeting omicron BA.4–BA.5 sublineages resulted in similar neutralization of other SARS-CoV-2 variants as a fourth... Boosting Vaccination with BA.4–BA.5 SequencesIn a small study, a bivalent mRNA vaccine targeting omicron BA.4–BA.5 sublineages resulted in similar...
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SubjectTerms	Antibodies Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Antibody Formation - immunology Antibody response Coronavirus COVID-19 - immunology COVID-19 - prevention & control COVID-19 - virology Humans Immunization Infections Infectious Disease mRNA mRNA vaccines Severe acute respiratory syndrome coronavirus 2 Vaccines Vaccines, Combined - immunology Vaccines, Combined - therapeutic use Viral Infections
SubjectTermsDisplay	Coronavirus Infectious Disease Vaccines Viral Infections
Title	Antibody Response to Omicron BA.4–BA.5 Bivalent Booster
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