Antibody Response to Omicron BA.4–BA.5 Bivalent Booster

Boosting Vaccination with BA.4–BA.5 SequencesIn a small study, a bivalent mRNA vaccine targeting omicron BA.4–BA.5 sublineages resulted in similar neutralization of other SARS-CoV-2 variants as a fourth dose of a monovalent mRNA vaccine.

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Bibliographic Details
Published inThe New England journal of medicine Vol. 388; no. 6; pp. 567 - 569
Main Authors Wang, Qian, Bowen, Anthony, Valdez, Riccardo, Gherasim, Carmen, Gordon, Aubree, Liu, Lihong, Ho, David D.
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 09.02.2023
Subjects
Antibodies
Antibodies, Neutralizing - immunology
Antibodies, Viral - immunology
Antibody Formation - immunology
Antibody response
Coronavirus
COVID-19 - immunology
COVID-19 - prevention & control
COVID-19 - virology
Humans
Immunization
Infections
Infectious Disease
mRNA
mRNA vaccines
Severe acute respiratory syndrome coronavirus 2
Vaccines
Vaccines, Combined - immunology
Vaccines, Combined - therapeutic use
Viral Infections
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Summary:Boosting Vaccination with BA.4–BA.5 SequencesIn a small study, a bivalent mRNA vaccine targeting omicron BA.4–BA.5 sublineages resulted in similar neutralization of other SARS-CoV-2 variants as a fourth dose of a monovalent mRNA vaccine.
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ObjectType-Correspondence-1
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMc2213907