Raising the decontamination level for thyroid hormone ingestions

• Published in: The American journal of emergency medicine Vol. 13; no. 1; pp. 9 - 13
• Main Authors: Tunget, Cynthia L, Clark, Richard F, Turchen, Steven G, Manoguerra, Anthony S
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Elsevier Inc 1995; Elsevier
• Subjects: Biological and medical sciences; Child, Preschool; Drug intoxications. Doping; Emergencies; Humans; Infant; levothyroxine; Medical sciences; overdose; pediatric; Pharmacology. Drug treatments; poisoning; Poisoning - therapy; Retrospective Studies; Thyroid hormones; Thyroxine - poisoning; toxic; toxic; overdose; levothyroxine; Thyroid hormones; poisoning; pediatric; Human; Treatment; Decontamination; Toxicity; Thyroid hormone; Infant; Poisoning; Diagnosis; Child; Dose activity relation
• ISSN: 0735-6757; 1532-8171
• DOI: 10.1016/0735-6757(95)90231-7

Ninety-two pediatric cases (age ⩽ 6 years) of acute thyroid hormone ingestions that were reported over a 20-month period to one American Association of Poison Control Centers (AAPCC)-certified regional poison center were reviewed to determine whether significant toxicity in pediatric patients is associated with acute ingestions of ⩽5 mg levothyroxine (T 4) equivalent of thyroid hormone and the highest-tolerated milligram-per-kilogram dose. Parameters evaluated included patient weight, amount ingested, drug preparation, treatment type, outcome, management site, and relevant comments. Eight patients had mild symptoms requiring no specific medical intervention and there was no correlation between the amount ingested and symptoms observed. The maximum T 4 dose ingested without gastrointestinal decontamination was 0.13 mg/kg (2 mg). A literature review was also conducted. Only one case of moderate toxicity with a dose of less than 5 mg T 4 equivalent was found in the literature review. Significant toxicity is not expected with ingestions of less than or equal to 5 mg T 4 equivalent of thyroid hormone.