Expression of alpha isoforms of the Na,K-ATPase in human heart

We studied expression of isoforms of Na,K-ATPase in normal and diseased human hearts. Na,K-ATPase alpha-isoform mRNA in samples from normal human left ventricle (LV) was composed of 62.5%, alpha 1, 15% alpha 2 and 22.5% alpha 3 on average. There was an increase in expression of the alpha 3 isoform i...

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Published inBiochimica et biophysica acta Vol. 1149; no. 2; pp. 189 - 194
Main Authors Zahler, R, Gilmore-Hebert, M, Baldwin, J C, Franco, K, Benz, Jr, E J
Format Journal Article
LanguageEnglish
Published Netherlands 04.07.1993
Subjects
Animals
Brain - enzymology
Cardiomyopathies - enzymology
Dogs
Gene Expression
Heart Ventricles
Humans
Isoenzymes - analysis
Kidney - enzymology
Myocardium - enzymology
RNA, Messenger - analysis
Sodium-Potassium-Exchanging ATPase - analysis
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Summary:We studied expression of isoforms of Na,K-ATPase in normal and diseased human hearts. Na,K-ATPase alpha-isoform mRNA in samples from normal human left ventricle (LV) was composed of 62.5%, alpha 1, 15% alpha 2 and 22.5% alpha 3 on average. There was an increase in expression of the alpha 3 isoform in samples from failing hearts, but expression of all three isoforms decreased in pressure-overloaded right ventricle (RV).
Bibliography:ObjectType-Article-1
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ISSN:0006-3002
DOI:10.1016/0005-2736(93)90200-J