The effect of infection on leukocyte and serum lysosomal enzyme activities in protein-calorie malnutrition

Representative leukocyte and serum lysosomal enzymes, namely B-glucuronidase, acid phosphatase and hexosaminidase, were studied in 53 protein-calorie malnourished children and 26 controls. The leukocyte lysosomal enzyme activities were elevated in non-infected malnourished children while significant...

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Published inNutrition research (New York, N.Y.) Vol. 9; no. 1; pp. 15 - 26
Main Authors Olomu, N.I., Paed, F.M.C., Omene, J.A., Glew, R.H.
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 1989
Elsevier Science
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Summary:Representative leukocyte and serum lysosomal enzymes, namely B-glucuronidase, acid phosphatase and hexosaminidase, were studied in 53 protein-calorie malnourished children and 26 controls. The leukocyte lysosomal enzyme activities were elevated in non-infected malnourished children while significant decreases in these enzymes were observed in the leukocytes of the infected malnourished group whose serum lysosomal hydrolase levels were also significantly elevated. These observed alterations in serum and leukocyte hydrolase activities may partially explain the impaired leukocyte microbicidal activity and the increased propensity for the development of endotoxic shock in children with protein-calorie-malnutrition.
Bibliography:S30
8904324
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ISSN:0271-5317
1879-0739
DOI:10.1016/S0271-5317(89)80100-9