Thyroid hormone treatment of primary unipolar depression: a review
A substantial number of depressed patients will fail to respond to standard antidepressant therapy. Thyroid hormones, particularly T3, may be particularly useful in enhancing response to antidepressants. This review focuses on the use of T3 augmentation in unipolar major depression. The study clearl...
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Published in | The international journal of neuropsychopharmacology Vol. 3; no. 2; pp. 143 - 147 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
Cambridge University Press
01.06.2000
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Subjects | |
Online Access | Get full text |
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Summary: | A substantial number of depressed patients will fail to respond to standard antidepressant therapy. Thyroid
hormones, particularly T3, may be particularly useful in enhancing response to antidepressants. This review
focuses on the use of T3 augmentation in unipolar major depression. The study clearly suggests that
approximately half of patients will respond to T3 augmentation of antidepressants. There are several
limitations to the literature including the fact that most studies have used T3 in tricyclic rather than SSRI failure
and most are of relatively short duration, up to 3 wk. Further studies are required of T3 efficacy with newer
classes of antidepressants, optimal dose of T3 to be used and the duration of T3 augmentation, particularly if
the acute trial is successful. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1461-1457 1469-5111 |
DOI: | 10.1017/S146114570000184X |