Evaluation of ameliorative potential of supranutritional selenium on enrofloxacin-induced testicular toxicity

• Published in: Chemico-biological interactions Vol. 252; pp. 87 - 92
• Main Authors: Rungsung, Soya, Khan, Adil Mehraj, Sood, Naresh Kumar, Rampal, Satyavan, Singh Saini, Simrat Pal
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 25.05.2016
• Subjects: Animals; Antineoplastic Agents - blood; Antineoplastic Agents - toxicity; Enrofloxacin; Fluoroquinolones - blood; Fluoroquinolones - toxicity; Male; Oxidative Stress - drug effects; Protective Agents - pharmacology; Rats; Rats, Wistar; Reproductive toxicity; Selenium; Selenium - pharmacology; Sperm Count; Sperm Motility - drug effects; Spermatogenesis - drug effects; Spermatozoa - drug effects; Spermatozoa - metabolism; Spermatozoa - pathology; Supranutritional; Testis - drug effects; Testis - metabolism; Testis - pathology; Testosterone - blood; Testosterone - metabolism; Supranutritional; Selenium; Reproductive toxicity; Enrofloxacin
• ISSN: 0009-2797; 1872-7786
• DOI: 10.1016/j.cbi.2016.04.018

The study was designed to assess the ameliorative potential of selenium (Se) on enrofloxacin-induced testicular toxicity in rats. There was a significant decrease in body weight and non-significant decrease in mean testicular weight of enrofloxacin treated rats. In enrofloxacin treated rats, total sperm count and viability decreased where as sperm abnormalities increased. Testicular histopathology revealed dose dependent dysregulation of spermatogenesis and presence of necrotic debris in seminiferous tubules which was marginally improved with Se. Enrofloxacin also produced a dose dependent decrease in testosterone level. The activity of testicular antioxidant enzymes decreased where as lipid peroxidation increased in a dose-dependent manner. Se supplementation partially restored oxidative stress and sperm damage and did not affect the plasma concentrations of enrofloxacin or ciprofloxacain. The results indicate that enrofloxacin produces a dose-dependent testicular toxicity in rats that is moderately ameliorated with supranutritional Se. •Enrofloxacin has gonadotoxic effect in male rats.•Enrofloxacin produces a dose dependent decrease in spermatogenic function and plasma testosterone level.•Supranutritional Se does not affect the plasma enrofloxacin and ciprofloxacin concentrations.•Supranutritional Se modulates enrofloxacin induced testicular oxidative stress.•Supranutritional Se moderately ameliorates enrofloxacin-induced testicular toxicity.