Cell cycle kinetics analysis of Hela cells exposed to aphidicolin: Computer simulation

• Published in: Computers in biology and medicine Vol. 22; no. 4; pp. 269 - 275
• Main Authors: Abed, Seraj Y., ElAssouli, Sufian M., Ozkul, Osman S., Alidrisi, Mustafa, Amer, Majed
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.07.1992; New York, NY Elsevier Science
• Subjects: Aphidicolin; Aphidicolin - pharmacology; Biological and medical sciences; Cell cycle; Cell Cycle - drug effects; Cells, Cultured; Computer Simulation; General aspects (metabolism, cell proliferation, established cell line...); Hela cells; HeLa Cells - cytology; HeLa Cells - drug effects; Humans; Medical sciences; Models, Biological; Simulation; Software; Synchronization; Tumor cell; Tumors; Hela cells; Simulation; Synchronization; Aphidicolin; Cell cycle; Cell proliferation; Cell culture; Computer simulation; Kinetics; Inhibition; Hela cell line; Tumor cell
• ISSN: 0010-4825; 1879-0534
• DOI: 10.1016/0010-4825(92)90066-V

A computer simulation model was developed and used to analyze the inhibitory effect of aphidicolin on the proliferation of Hela cells. Simulation results were compared with actual experimental results [Pedrali-Noy et al. (1980) Nuc. Acid Res. 8, 377] and were found to be in good agreement. Also, the simulation showed that aphidicolin caused cells to be accumulated at the G 1/S boundary and that recruitment and synchrony occurred.