Intracellular pH changes induced by exposure to weak acids and bases in submandibular cells of early postnatal rats

• Published in: Archives of oral biology Vol. 37; no. 9; pp. 699 - 703
• Main Authors: Seagrave, JC, Curry, M., Ramsey, R.Chaney, Martinez, J.R.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.09.1992; Elsevier Science
• Subjects: [formula omitted] antiport; Acetylcholine - pharmacology; Aging; Amiloride - pharmacology; Ammonium Chloride - pharmacology; Animals; Biological and medical sciences; Bumetanide - pharmacology; Butyrates - pharmacology; Butyric Acid; calcium; Cells, Cultured; Dentistry; development; Fundamental and applied biological sciences. Psychology; Hydrogen-Ion Concentration; intracellular pH; Ionomycin - pharmacology; Male; Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus; neonates; Rats; Rats, Sprague-Dawley; submandibular gland; Submandibular Gland - cytology; Submandibular Gland - drug effects; Submandibular Gland - physiology; Substance P - pharmacology; Time Factors; Vertebrates: digestive system; development; calcium; intracellular pH; neonates; submandibular gland; Na + H + antiport; Rat; Digestive system; Weak base; Rodentia; Submandibular gland; Ion transport; Salivary gland; Postnatal development; Vertebrata; Mammalia; pH; Intracellular; Weak acid

The intracellular pH of submandibular cells of adult, 1-day-old and 1-week-old rats was measured with the pH sensitive fluorimetric indicator SNARF-1, following shifts induced by exposure to a weak acid (sodium butyrate) or a weak base (NH 4Cl). The effects of several ion transport inhibitors and ag...