Intersectionality of Socioecological Factors Associated With Cognitive Function Among Older Women With HIV in the United States: A Structural Equation Model Analysis Using Data From the Women's Interagency HIV Study

Increased life expectancy of people with HIV has health implications including the intersection of the long-term use of antiretroviral treatment, inflammatory events, and age-related immunosenescence. In a cross-sectional study utilizing using the Socio-Eecological Model, we identified pathways of c...

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Bibliographic Details
Published inThe Journal of the Association of Nurses in AIDS Care Vol. 34; no. 1; pp. 83 - 95
Main Authors Njie-Carr, Veronica P S, Zhu, Shijun, Stafford, Kristen A, Tong, Weiqun, Plankey, Michael, Sharma, Anjali, Milam, Joel, Cohen, Mardge, Diaz, Monica M, Rubtsova, Anna A, Fischl, Margaret A, Konkle-Parker, Deborah, Gustafson, Deborah, Rubin, Leah H
Format Journal Article
LanguageEnglish
Published United States Lippincott Williams & Wilkins Ovid Technologies 01.01.2023
Subjects
Age differences
Aged
Alcohol use
Antiretroviral drugs
Antiretroviral therapy
Cognition
Cognition & reasoning
Cognitive functioning
Comorbidity
Cross-Sectional Studies
Female
HIV
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - epidemiology
Human immunodeficiency virus
Humans
Intersectional Framework
Intersectionality
Life expectancy
Mental depression
Older people
Older women
Race
Smoking
Structural equation modeling
Substance abuse
United States - epidemiology
Womens health
United States
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Summary:Increased life expectancy of people with HIV has health implications including the intersection of the long-term use of antiretroviral treatment, inflammatory events, and age-related immunosenescence. In a cross-sectional study utilizing using the Socio-Eecological Model, we identified pathways of cognitive function (CF) among 448 women with HIV, 50 years and older. A structural equation model showed the direct effects of mood (β = -0.25, p < .01), comorbidities (β = --0.13, p < .05), race (β = --0.13, p < .05), and abuse (β = 0.27, p < .001) on the latent variable CF. Substance and alcohol use, depressive symptoms, cigarette smoking, and the number of comorbidities are important considerations when designing interventions utilizing using a multi-level and intersectional lens to maximize positive CF outcomes.
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All authors on this paper meet the four criteria for authorship as identified by the International Committee of Medical Journal Editors (ICMJE): All authors contributed to the acquisition and interpretation of data, contributed to the intellectual content, were involved in revising the manuscript, reviewed the final version before submission, and agreed to be accountable for all aspects of the work.
Specifically, using the CRediT taxonomy, the specific contributions of each author is as follows: Conceptualization and Writing−original draft: V. P.S. Njie-Carr; Methodology, Formal Analysis, Project Administration, Resources, and Visualization: V.P.S. Njie-Carr and S. Zhu; Validation: D. Gustafson and L.H. Rubin; Writing– review and editing: V.P.S. Njie-Carr, S. Zhu, K. Stafford, W. Wong, M. Plankey, A. Sharma, J. Milam, M. Cohen, M. M. Diaz, A.A. Rubtsova, M.A. Fischl, D. Konkle-Parker, D. Gustafson, and R.H. Rubin.
Author Contributions
ISSN:1055-3290
1552-6917
DOI:10.1097/JNC.0000000000000376