The immune-metabolic regulatory roles of epoxyeicosatrienoic acids on macrophages phenotypic plasticity in obesity-related insulin resistance

• Published in: Prostaglandins & other lipid mediators Vol. 139; pp. 36 - 40
• Main Authors: Dai, Meiyan, Wu, Lujin, Tu, Ling, Xu, Xizhen, Wang, Dao Wen
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2018
• Subjects: Epoxyeicosatrienoic acids; Inflammation; Insulin resistance; Macrophage polarization; Epoxyeicosatrienoic acids; Insulin resistance; Inflammation; Macrophage polarization
• ISSN: 1098-8823
• DOI: 10.1016/j.prostaglandins.2018.10.003

•We briefly summarize the macrophages recruitment, infiltration and polarization in obese mice.•We elaborate the relationship of CYP epoxygenases, EETs, sEH and metabolic diseases.•We discuss the importance roles of EETs on macrophages phenotypic plasticity in obesity-related insulin resistance. Macrophages in adipose tissue are associated with obesity-induced low-grade inflammation, which contributed to insulin resistance and the related metabolic diseases. Macrophages display phenotypic plasticity, and polarize under the condition of obesity. Epoxyeicosatrienoic Acids (EETs) are lipid mediators that are involved in the regulation of inflammatory cascades and glucose homeostasis. In this mini-review, we briefly summarize the macrophages recruitment, infiltration and polarization in obese mice, and also discuss the immune-metabolic regulatory role of EETs in this process (See Fig. 1).