Nasal oral fistula revealing Langerhans' cell histiocytosis in adult patient: case report

Langerhans cell histiocytosis (LCH) is a rare systemic disease caused by proliferation of mature histiocytes; its association to histiocyto fibroma is rarely reported. It rarely affects adults. We report a case of systemic LCH, in an adult patient with osteolytic lesion causing a fistula between the...

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Bibliographic Details
Published inThe Pan African medical journal Vol. 40
Main Authors Mzabi, Anis, Thabet, Maissa, Tlili, Taghrid, Zorgati, Hend, Anoun, Jihed, Hassine, Imen Ben, Karmeni, Monia, Fredj, Fatma Ben, Mokni, Moncef, Laouani, Chadia
Format Journal Article
LanguageEnglish
Published Kampala African Field Epidemiology Network 06.09.2021
The African Field Epidemiology Network
Subjects
Adults
Autoimmune diseases
Biopsy
Case Report
Case reports
Chemotherapy
Cysts
Fistula
Lymphatic system
Patients
Tunisia
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Summary:Langerhans cell histiocytosis (LCH) is a rare systemic disease caused by proliferation of mature histiocytes; its association to histiocyto fibroma is rarely reported. It rarely affects adults. We report a case of systemic LCH, in an adult patient with osteolytic lesion causing a fistula between the left nasal cavity and hard palate, involving the bone, lung, lymph node and associated to multiple histiocyto fibroma. The patient was operating for a fistula, and he was treated by chemotherapy and corticosteroids. Langerhans´ cell histiocytosis is a rare case, especially in adult patient. The diagnosis was based on histological and immunohistochemical analyses. This patient was treated by steroids and chemotherapy.
ISSN:1937-8688
1937-8688
DOI:10.11604/pamj.2021.40.16.27074