Effects of aging and endotoxin on hepatic glucocorticoid action and glucose metabolism in mice

• Published in: Mechanisms of ageing and development Vol. 30; no. 1; pp. 73 - 78
• Main Authors: Stith, R.D., McCallum, R.E.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.04.1985; Elsevier Science
• Subjects: [ 3H] Dexamethasone; Age; Aging; Animals; Biological and medical sciences; Blood Glucose - metabolism; Corticosterone - blood; Endotoxin; Endotoxins - pharmacology; Fundamental and applied biological sciences. Psychology; Glucose; Glucose - metabolism; Liver - drug effects; Liver - metabolism; Liver Glycogen - metabolism; Liver. Bile. Biliary tracts; Male; Metabolism; Mice; Mice, Inbred C3H; Phosphoenolpyruvate Carboxykinase (GTP) - metabolism; Receptors, Glucocorticoid - metabolism; Receptors, Steroid - metabolism; Vertebrates: digestive system; Mice; Glucose; Metabolism; Endotoxin; Age; [ 3H] Dexamethasone; Vertebrata; Mammalia; Mouse; Steroid hormone; Liver; Ageing; Rodentia; Glucocorticoid
• ISSN: 0047-6374; 1872-6216
• DOI: 10.1016/0047-6374(85)90060-0

Hepatic binding of [ 3H] dexamethasone, phosphoenolpyruvate carboxykinase activity, glycogen levels, and plasma glucose and corticosterone concentrations were measured in young, mature, and old mice given either endotoxin or vehicle. Endotoxin treatment differentially lowered plasma glucose concentration, hepatic glycogen content, PEPCK activity and specifically bound [ 3H] dexamethasone, but increased plasma corticosterone concentration by a magnitude dependent upon the age of the animal.