Effects of dibutyryl cyclic GMP on rabbit pancreas secretion

• Published in: Biochimica et biophysica acta Vol. 761; no. 3; pp. 252 - 256
• Main Authors: Kuijpers, G.A.J., van Nooy, I.G.P., De Pont, J.J.H.H.M., Bonting, S.L.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 27.12.1983; Elsevier; North-Holland
• Subjects: Animals; Biological and medical sciences; Bucladesine - pharmacology; Cell Membrane Permeability - drug effects; Cell physiology; Cholecystokinin; Cholecystokinin - pharmacology; dibutyryl cyclic GMP; Fundamental and applied biological sciences. Psychology; Molecular and cellular biology; Pancreas - drug effects; Pancreas - metabolism; Pancreatic Juice - drug effects; Pancreatic Juice - metabolism; Pancreozymin; Protein secretion; Proteins - metabolism; Rabbit pancreas; Rabbits; Secretion. Exocytosis; Sincalide - pharmacology; Sucrose - metabolism; Protein secretion; Rabbit pancreas; dibutyryl cyclic GMP; Pancreozymin; Cholecystokinin; C terminal peptide; Secretion; Peptide hormone; Rabbit; Permeability; Lagomorpha; Proteins; Vertebrata; Mammalia; Inhibition; Pancreas; Hormonal receptor
• ISSN: 0304-4165; 0006-3002; 1872-8006; 1878-2434
• DOI: 10.1016/0304-4165(83)90073-9

The isolated rabbit pancreas responds to the hormone cholecystokinin-pancreozymin and its C-terminal peptide with increases in protein secretion and in paracellular permeability. Dibutyryl cyclic GMP competitively inhibits these responses to the C-terminal octapeptide, but with different sensitivity. In low concentrations dibutyryl cyclic GMP lowers only the increase in the paracellular permeability, whereas in high concentrations it inhibits both the protein secretion and the permeability increase. The effect can be explained by assuming competition between dibutyryl cyclic GMP and the hormone at the level of the pancreozymin receptors.