Cellular Senescence revisited: a review

• Published in: Mechanisms of ageing and development Vol. 38; no. 1; pp. 1 - 48
• Main Author: Stanulis-Praeger, BetzabéM.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.03.1987; Elsevier Science
• Subjects: Adult donors; Ageing, cell death; Aging; Biological and medical sciences; Blood; Cell Division; Cell Fusion; Cell Line; Cell physiology; Cell Survival; Cell Transformation, Neoplastic; Cellular senescence; Epidermal Cells; Fibroblasts; Fibroblasts - physiology; Fundamental and applied biological sciences. Psychology; Growth Substances - pharmacology; Humans; Keratinocytes; Keratins; Molecular and cellular biology; Fibroblasts; Keratinocytes; Cellular senescence; Adult donors; Keratinocyte; Senescence; Review; Cell; Fibroblast
• ISSN: 0047-6374; 1872-6216
• DOI: 10.1016/0047-6374(87)90109-6

The field of cellular senescence (cytogerontology) is reviewed. The historical precedence for investigation in this field is summarized, and placed in the context of more recent studies of the regulation of cellular proliferation and differentiation. The now-classical embryonic lung fibroblast model is compared to models is compared to models utilizing other cell types as well as cells from donors of different ages and phenotypes. Modulation of cellular senescence by growth factors, hormones, and genetic manipulation is contrasted, but newer studies in oncogene involvement are omitted. A current consensus would include the view that the life span of normal diploid cells in culture is limited, is under genetic control, and is capable of being modified. Finally, embryonic cells aging in vitro share certain characteristics with early passage cells derived from donors of increasing age.