ATP-stimulated uptake of S-(2,4-dinitrophenyl)glutathione by plasma membrane vesicles from rat liver

ATP-stimulated uptake of S-(2,4-dinitrophenyl)glutathione with a high activity of 0.35 nmol/min per mg protein is found in a rat liver plasma membrane vesicle preparation enriched in sinusoidal marker enzymes. Transport takes place into an osmotically active space. Vanadate and S-(azidophenacyl)glut...

Full description

Saved in:
Bibliographic Details
Published inBiochimica et biophysica acta Vol. 983; no. 1; pp. 123 - 125
Main Authors KUNST, M, SIES, H, AKERBOOM, T. P. M
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier 24.07.1989
North-Holland
Subjects
Adenosine Triphosphate - metabolism
Adenosine Triphosphate - pharmacology
Animals
Biological and medical sciences
Biological Transport - drug effects
Cell Membrane - drug effects
Cell Membrane - metabolism
Cell physiology
Fundamental and applied biological sciences. Psychology
Glutathione - analogs & derivatives
Glutathione - metabolism
Kinetics
Liver - metabolism
Membrane and intracellular transports
Molecular and cellular biology
Osmolar Concentration
Rats
Calcium
Radiolabelling
Rat
Liver
Rodentia
Vertebrata
Mammalia
Membrane transport
Plasma membrane
Kinetics
ATP
Derived product
Glutathione
Online AccessGet full text

Cover

More Information
Summary:ATP-stimulated uptake of S-(2,4-dinitrophenyl)glutathione with a high activity of 0.35 nmol/min per mg protein is found in a rat liver plasma membrane vesicle preparation enriched in sinusoidal marker enzymes. Transport takes place into an osmotically active space. Vanadate and S-(azidophenacyl)glutathione inhibit transport, whereas Ca2+, EGTA and ouabain are without effect.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0006-3002
1878-2434
DOI:10.1016/0005-2736(89)90389-1