Renal artery stenosis in heart failure

• Published in: The American journal of cardiology Vol. 62; no. 17; pp. 1307 - 1308
• Main Authors: Meissner, Marc D., Wilson, Audrey R., Jessup, Mariell
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.12.1988; Elsevier
• Subjects: Aged; Biological and medical sciences; Captopril - therapeutic use; Coronary Disease - complications; Heart Failure - complications; Humans; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Renal Artery Obstruction - etiology; Renovascular diseases; Human; Hypertension; Heart failure; Urinary system disease; Renal artery; Heart disease; Stenosis; Cardiovascular disease; Complication
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/0002-9149(88)90283-4

Captopril, an oral angiotensin-converting enzyme inhibitor, has proven to be effective in the management of congestive heart failure (CHF). 1 Several trials have documented short- and long-term hemodynamic and clinical improvement with captopril therapy, including increased exercise tolerance. 2,3 However, captopril may fail to improve or be detrimental to renal function 4 in some patients, particularly if accompanied by marked decreases in systemic pressures. Recent reports have described captopril-induced renal insufficiency in patients with bilateral renal artery stenosis or unilateral stenosis in a solitary kidney 5 and in renal transplant recipients with hypertension. 6 Herein we describe certain findings in 6 of 89 patients with significant CHF seen in a 10-month period in whom a diagnosis of significant renal artery stenosis was made.