Epidemiology of mobile colistin resistance genes mcr-1 to mcr-9

Abstract The identification of the first mobile colistin resistance (MCR) gene, mcr-1, in 2015 triggered a rash of mcr screening reports. Subsequently, nine MCR-family genes and their variants have been described. However, a comprehensive overview concerning the epidemiology of the whole MCR family,...

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Bibliographic Details
Published inJournal of antimicrobial chemotherapy Vol. 75; no. 11; pp. 3087 - 3095
Main Authors Ling, Zhuoren, Yin, Wenjuan, Shen, Zhangqi, Wang, Yang, Shen, Jianzhong, Walsh, Timothy R
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.11.2020
Subjects
Anti-Bacterial Agents - pharmacology
Colistin - pharmacology
Drug Resistance, Bacterial - genetics
Escherichia coli
Escherichia coli Proteins - genetics
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Summary:Abstract The identification of the first mobile colistin resistance (MCR) gene, mcr-1, in 2015 triggered a rash of mcr screening reports. Subsequently, nine MCR-family genes and their variants have been described. However, a comprehensive overview concerning the epidemiology of the whole MCR family, which is essential for facilitating rational interventions against mcr dissemination, is lacking. Here, based on the National Database of Antibiotic Resistant Organisms and published studies, we have summarized the latest epidemiological characteristics of the mcr genes.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0305-7453
1460-2091
1460-2091
DOI:10.1093/jac/dkaa205