Nutrition Assessment and Adverse Outcomes in Hospitalized Patients with Tuberculosis

• Published in: Journal of clinical medicine Vol. 10; no. 12; p. 2702
• Main Authors: Lin, Huang-Shen, Lin, Ming-Shyan, Chi, Ching-Chi, Ye, Jung-Jr, Hsieh, Ching-Chuan
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 18.06.2021; MDPI
• Subjects: Abscesses; Arthritis; Body mass index; Cardiovascular disease; Chronic illnesses; Chronic obstructive pulmonary disease; Clinical medicine; Comorbidity; Demography; Diabetes; Hematology; Hospitals; Liver; Malnutrition; Metabolism; Multivariate analysis; Nutrition; Nutritional status; Patients; Tuberculosis; Urogenital system
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm10122702

Background: Malnutrition in patients with tuberculosis (TB) is associated with poor outcomes. This study assessed the validity of the patient-generated subjective global assessment (PG-SGA) in adult TB patients and examined the association of the PG-SGA score with adverse outcomes. Methods: This is a retrospective chart review study compared with the well-nourished and malnourished TB patients. The nutritional status was determined using the PG-SGA for adult patients (n = 128). Clinical outcomes included liver injury and mortality. Adverse outcomes included hepatitis during anti-tuberculosis therapy. Results: By comparing nutritional status using global assessment, well-nourished patients had a significantly higher body weight index (p = 0.002), a lower PG-SGA score (p < 0.001), and lower diabetic rate (p = 0.029). Malnourishment was a risk factor (p = 0.022) for liver injury and fatal outcomes (p < 0.001). A higher PG-SGA score was a risk factor for liver injury (p = 0.002) and an independent risk factor for fatal outcomes (p = 0.031). ROC analysis for outcome prediction showed that a PG-SGA score of 5.5 points yielded the most appropriate sensitivity (61.5%) and specificity (64.7%). Conclusion: Both global assessment and the total PG-SGA score were related to tuberculosis outcome and liver injury during anti-TB treatment.