Association between Interleukin-10-1082 G/A and Tumor Necrosis Factor-α 308 G/A Gene Polymorphisms and Respiratory Distress Syndrome in Iranian Preterm Infants

• Published in: Mediators of inflammation Vol. 2017; no. 2017; pp. 1 - 8
• Main Authors: Hamidi, Majid, Moradi, Fahimeh, Omidvari, Peyman, Kheiri, Soleiman, Khoshdel, Abolfazl, Teimori, Hossein
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2017; Hindawi; Wiley
• Subjects: Adolescent; Adult; Alleles; Case-Control Studies; Cross-Sectional Studies; Female; Genotype; Gestational Age; Humans; Incidence; Infant, Premature; Interleukin-10 - genetics; Iran; Male; Middle Aged; Polymorphism, Genetic; Prevalence; Respiratory Distress Syndrome, Newborn - epidemiology; Respiratory Distress Syndrome, Newborn - genetics; Surface-Active Agents - chemistry; Tumor Necrosis Factor-alpha - genetics; Young Adult
• ISSN: 0962-9351; 1466-1861
• DOI: 10.1155/2017/6386453

Cytokine polymorphisms may contribute to the prevalence of respiratory distress syndrome. The present study was done to investigate the frequency of interleukin- (IL-) 10 and tumor necrosis factor- (TNF-) α gene polymorphisms and their association with the risk of RDS in preterm infants. One-hundred and nineteen patients with RDS and 119 healthy preterm infants were enrolled. PCR restriction fragment length polymorphism was used to determine the frequency of IL-10 and TNF-α genotypes at -1082 A and -308 A, respectively. One-hundred and nineteen out of 238 infants had RDS (50%). The age of the mothers and gestational age ranged 17–45 (mean: 28.6±5.3) years and 24–34 (mean: 34.3±2.38) weeks, respectively. Totally, 23 deaths were recorded in the RDS group. Incidence of TNF-α-308 A/A and TNF-α-308 G/A was 84% and 16%, respectively. TNF-a-308 G/G was not found in both groups. Prevalence of IL-10-1082 G/G and IL-10-1082 G/A variants was 65.5% and 34.5%, respectively. IL-10-1082 A/A was not found in both groups. The incidence of the allele G in the IL-10-1082 polymorphism was lower in RDS group (P<0.05). We found that the risk of RDS was correlated to sex, gestational age, and IL-10-1082.