Effects of nifedipine and TMB-8 on renal vasoconstriction induced by hypertonic saline in dogs
Intrarenal arterial infusion of hypertonic saline (+ 30 mEq/1 NaCl in renal plasma) reduced renal blood flow and glomerular filtration rate with little change in filtration fraction in anesthetized dogs. The blood flow and the filtration rate responses were suppressed during infusion of nifedipine (...
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Published in | European journal of pharmacology Vol. 243; no. 1; pp. 103 - 106 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Amsterdam
Elsevier B.V
12.10.1993
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Intrarenal arterial infusion of hypertonic saline (+ 30 mEq/1 NaCl in renal plasma) reduced renal blood flow and glomerular filtration rate with little change in filtration fraction in anesthetized dogs. The blood flow and the filtration rate responses were suppressed during infusion of nifedipine (0.1 μg/kg per min). TMB-8 (50 μg/kg per min) also suppressed the blood flow response but not the filtration rate response. These results suggest that preglomerular vasoconstriction during hypertonic saline infusion requires Ca
2+ influx via voltage-dependent Ca
2+ channels and that hypertonic saline slightly contracts postglomerular vessels by activating a TMB-8-sensitive Ca
2+ movement pathway. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0014-2999 1879-0712 |
DOI: | 10.1016/0014-2999(93)90176-I |