Effects of nifedipine and TMB-8 on renal vasoconstriction induced by hypertonic saline in dogs

• Published in: European journal of pharmacology Vol. 243; no. 1; pp. 103 - 106
• Main Authors: Ogasawara, Aichi, Hisa, Hiroaki, Satoh, Susumu
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 12.10.1993; Elsevier
• Subjects: Animals; Biological and medical sciences; Calcium Channel Blockers - pharmacology; Dogs; Female; Fundamental and applied biological sciences. Psychology; Gallic Acid - analogs & derivatives; Gallic Acid - pharmacology; Glomerular filtration rate; Glomerular Filtration Rate - drug effects; Hypertonic saline; Kidney - blood supply; Male; Nifedipine; Nifedipine - pharmacology; Renal blood flow; Renal Circulation - drug effects; Sodium Chloride - pharmacology; TMB-8 (8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate); Vasoconstriction - drug effects; Vertebrates: urinary system; TMB-8 (8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate); Renal blood flow; Hypertonic saline; Nifedipine; Glomerular filtration rate; Fissipedia; Carnivora; Glomerular filtration; Renal function; Calcium; Calcium antagonist; Vasoconstriction; Ionic channel; Kidney; Dihydropyridine derivative; Blood flow; Vertebrata; Mammalia; Urinary system; Blood vessel; Circulatory system; Hemodynamics; Mechanism of action; Dog; Hypertonic solution
• ISSN: 0014-2999; 1879-0712
• DOI: 10.1016/0014-2999(93)90176-I

Intrarenal arterial infusion of hypertonic saline (+ 30 mEq/1 NaCl in renal plasma) reduced renal blood flow and glomerular filtration rate with little change in filtration fraction in anesthetized dogs. The blood flow and the filtration rate responses were suppressed during infusion of nifedipine (0.1 μg/kg per min). TMB-8 (50 μg/kg per min) also suppressed the blood flow response but not the filtration rate response. These results suggest that preglomerular vasoconstriction during hypertonic saline infusion requires Ca 2+ influx via voltage-dependent Ca 2+ channels and that hypertonic saline slightly contracts postglomerular vessels by activating a TMB-8-sensitive Ca 2+ movement pathway.