Novel NGF-potentiating limonoids from the fruits of Melia toosendan

Four new limonoids (1–4), together with five known limonoids (5–9), were isolated from the fruits of Melia toosendan. Their structures were elucidated based on extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, IR, [α]D). The isolated compounds were evaluated for their neurite outgrowth-prom...

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Bibliographic Details
Published inFitoterapia Vol. 90; pp. 192 - 198
Main Authors Zhang, Qiong, Li, Jian-Kuan, Ge, Rui, Liang, Jing-Yu, Li, Qing-Shan, Min, Zhi-Da
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.10.2013
Subjects
Animals
Fruit
fruits
Limonins - chemistry
Limonins - isolation & purification
Limonins - pharmacology
Limonoid
limonoids
Melia - chemistry
Melia azedarach
Melia toosendan
Meliaceae
Molecular Structure
Nerve Growth Factor - metabolism
Neurite outgrowth-promoting activity
Neurites - drug effects
Nimbolinin
PC12 Cells
Plant Extracts - chemistry
Plant Extracts - pharmacology
Rats
spectroscopy
Melia toosendan
Limonoid
Neurite outgrowth-promoting activity
Nimbolinin
Meliaceae
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Summary:Four new limonoids (1–4), together with five known limonoids (5–9), were isolated from the fruits of Melia toosendan. Their structures were elucidated based on extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, IR, [α]D). The isolated compounds were evaluated for their neurite outgrowth-promoting activities. Compounds 2 and 6 significantly enhanced NGF-mediated neurite outgrowth in PC12 cells at concentrations ranging from 0.1 to 50.0μM. [Display omitted]
Bibliography:http://dx.doi.org/10.1016/j.fitote.2013.07.019
ISSN:0367-326X
1873-6971
DOI:10.1016/j.fitote.2013.07.019