General and fast synthesis of graphene frameworks using sugars for high-performance hydrogen peroxide nonenzymatic electrochemical sensor

• Published in: Mikrochimica acta (1966) Vol. 187; no. 12; p. 669
• Main Authors: Zhu, Yanyan, Kang, Kai, Jia, Yutao, Guo, Wei, Wang, Jing
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.12.2020; Springer
• Subjects: Analytical Chemistry; Catalysis; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Electrochemical Techniques - methods; Electrodes; Fructose; Graphene; Graphite; Graphite - chemistry; Hydrogen peroxide; Hydrogen Peroxide - analysis; Lactose; Lactose - chemistry; Microengineering; Nanochemistry; Nanotechnology; Original Paper; Reproducibility of Results; Sensors; Sucrose - chemistry; Uric acid; Graphene framework; Electrocatalytic activity; Hydrogen peroxide; Electrochemical sensor; Nonenzymatic
• ISSN: 0026-3672; 1436-5073
• DOI: 10.1007/s00604-020-04607-x

3D graphene frameworks (GFs) are fast and scalably synthesized via a general and facile method from the rich biomass of sugars with the aid of molten salts, using glucose as the prototype, to obtain an effective sensing platform for sensitive nonenzymatic hydrogen peroxide (H 2 O 2 ) detection. The electroactive area of the GFs/GCE (0.1437 cm 2 ) is obviously higher than that of bare GCE (0.0653 cm 2 ). The GFs are found to exhibit remarkable electrocatalytic activity toward H 2 O 2 reduction while avoiding enzyme loading. The electrochemical sensor for H 2 O 2 based on GFs displays a low detection limit of 0.032 ± 0.005 μM (S/ N  = 3) at a working potential of − 0.55 V in 0.01 M N 2 -saturated phosphate-buffered saline (PBS, pH = 7.4) by an amperometric method. The sensor has good selectivity over other compounds such as ascorbic acid, dopamine, uric acid, NaCl, citric acid, and glucose. Moreover, the sensor shows excellent reproducibility with a relative standard deviation of 3.7% and acceptable stability after 30 days of usage. Furthermore, it can detect H 2 O 2 released from living tumorigenic cells in real time. Most importantly, it is demonstrated that such GFs can be obtained from a variety of sugars (sucrose, fructose, lactose, and maltose). This work may offer a new general avenue for the synthesis of 3D GFs and promote the development of electrochemical sensors. Graphical abstract We have reported a general and fast method to synthesize GFs from sugars (glucose, sucrose, fructose, lactose, and maltose) with the addition of molten Na 2 CO 3 salt as a template. The developed GFs can be applied as excellent electrode materials for efficient electrochemical sensing of H 2 O 2 .