Evaluation by larval recovery of mebendazole activity in experimental murine toxocariasis

• Published in: International journal for parasitology Vol. 25; no. 5; pp. 587 - 592
• Main Authors: BARDON, R, CUELLAR, C, GUILLEN, J. L
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.05.1995; Elsevier Science
• Subjects: [formula omitted] mice; Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiparasitic agents; Biological and medical sciences; Brain - parasitology; Drug Administration Schedule; experimental murine toxocariasis; hepatopulmonary phase; Larva; larval recovery; Liver - parasitology; Lung - parasitology; Male; mebendazole; Mebendazole - administration & dosage; Medical sciences; Mice; Mice, Inbred BALB C; Musculoskeletal System - parasitology; myotropic-neurotropic phase; Pharmacology. Drug treatments; Toxocara canis - growth & development; Toxocariasis - drug therapy; Toxocariasis - parasitology; BALB c mice; mebendazole; larval recovery; experimental murine toxocariasis; hepatopulmonary phase; myotropic-neurotropic phase; Toxocara canis; Anthelmintic; Treatment efficiency; Rodentia; Larva migrans; Parasite; Parasitosis; Experimental study; Helminthiasis; Recovery; Biological activity; Infection; Vertebrata; Mammalia; Nematod disease; Larva; Mouse; Animal; Parasiticid; Helmintha; Toxocariasis; Nemathelminthia; Invertebrata; Nematoda
• ISSN: 0020-7519; 1879-0135
• DOI: 10.1016/0020-7519(94)00155-H

We have studied the action of mebendazole on experimental murine toxocariasis using different formulations and vehicles. The treatment efficacy was evaluated by larval recovery after digesting several tissues. In the first part of the experiment, the drugs were administered on days 1–3 post infection (p.i.) inclusive (hepato-pulmonary phase of the migration), then the animals were sacrificed by the 1st week p.i. In the second part of the experimental protocol, the treatments were administered on days 4–6 p.i. inclusive (myotropic-neurotropic phase of the migration), with sacrifice of the animals by the 7th week p.i. The 2nd pattern of treatment reduced more effectively the total larval recoveries compared with control animals. However, the larval distribution by organs was scarcely affected. The first pattern of treatment reduced less effectively the total number of larvae, but it significantly inhibited migration.