Adenosine induces a calcium-dependent glomerular contraction
Glomeruli isolated from rat kidney cortex were incubated with adenosine in the presence or absence of verapamil and calcium and their change in cross-sectional area was recorded. Adenosine induced a 10% decrease in glomerular cross-sectional area. This decrease was blocked by verapamil or a calcium-...
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| Published in | European journal of pharmacology Vol. 134; no. 3; p. 365 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
24.02.1987
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| Subjects | |
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| Abstract | Glomeruli isolated from rat kidney cortex were incubated with adenosine in the presence or absence of verapamil and calcium and their change in cross-sectional area was recorded. Adenosine induced a 10% decrease in glomerular cross-sectional area. This decrease was blocked by verapamil or a calcium-free medium. The results suggest that the effect of adenosine in the kidney could be due to glomerular constriction, and that this constriction depends on the entry of calcium into glomerular cells. |
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| AbstractList | Glomeruli isolated from rat kidney cortex were incubated with adenosine in the presence or absence of verapamil and calcium and their change in cross-sectional area was recorded. Adenosine induced a 10% decrease in glomerular cross-sectional area. This decrease was blocked by verapamil or a calcium-free medium. The results suggest that the effect of adenosine in the kidney could be due to glomerular constriction, and that this constriction depends on the entry of calcium into glomerular cells. |
| Author | Rodriguez-Puyol, D de Arriba, G López-Novoa, J M Barrio, V |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/3569420$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_pharmthera_2016_07_011 crossref_primary_10_1038_ki_1993_50 crossref_primary_10_1007_s11010_007_9540_4 crossref_primary_10_1016_j_vph_2013_01_001 crossref_primary_10_1016_0024_3205_88_90220_2 crossref_primary_10_1111_j_1476_5381_1992_tb14505_x crossref_primary_10_1038_ki_1989_126 crossref_primary_10_1016_S0928_0987_00_00198_6 crossref_primary_10_1038_ki_1991_74 crossref_primary_10_1254_jjp_63_257 crossref_primary_10_1254_jjp_63_513 crossref_primary_10_1211_0022357021778330 crossref_primary_10_1111_j_1476_5381_1992_tb12748_x crossref_primary_10_1038_ki_1993_130 crossref_primary_10_1038_ki_1996_173 crossref_primary_10_1016_S0898_6568_96_00091_5 crossref_primary_10_1111_j_2042_7158_1991_tb06651_x |
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| SubjectTerms | Adenosine - pharmacology Animals Calcium - physiology In Vitro Techniques Kidney Glomerulus - drug effects Muscle, Smooth - drug effects Rats Rats, Inbred Strains |
| Title | Adenosine induces a calcium-dependent glomerular contraction |
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