Adenosine induces a calcium-dependent glomerular contraction

Glomeruli isolated from rat kidney cortex were incubated with adenosine in the presence or absence of verapamil and calcium and their change in cross-sectional area was recorded. Adenosine induced a 10% decrease in glomerular cross-sectional area. This decrease was blocked by verapamil or a calcium-...

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Bibliographic Details
Published inEuropean journal of pharmacology Vol. 134; no. 3; p. 365
Main Authors López-Novoa, J M, de Arriba, G, Barrio, V, Rodriguez-Puyol, D
Format Journal Article
LanguageEnglish
Published Netherlands 24.02.1987
Subjects
Adenosine - pharmacology
Animals
Calcium - physiology
In Vitro Techniques
Kidney Glomerulus - drug effects
Muscle, Smooth - drug effects
Rats
Rats, Inbred Strains
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Summary:Glomeruli isolated from rat kidney cortex were incubated with adenosine in the presence or absence of verapamil and calcium and their change in cross-sectional area was recorded. Adenosine induced a 10% decrease in glomerular cross-sectional area. This decrease was blocked by verapamil or a calcium-free medium. The results suggest that the effect of adenosine in the kidney could be due to glomerular constriction, and that this constriction depends on the entry of calcium into glomerular cells.
ISSN:0014-2999
DOI:10.1016/0014-2999(87)90371-2