Environmental microcystin exposure triggers the poor prognosis of prostate cancer: Evidence from case-control, animal, and in vitro studies

• Published in: Journal of environmental sciences (China) Vol. 127; pp. 69 - 81
• Main Authors: Pan, Chun, Qin, Haixiang, Yan, Minghao, Qiu, Xuefeng, Gong, Wenyue, Luo, Wenxin, Guo, Hongqian, Han, Xiaodong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2023
• Subjects: Animals; blood serum; Cadherins; Case-Control Studies; China; E-cadherin; Epithelial-mesenchymal transition (EMT); Estrogen Receptor alpha; Estrogen receptor-α (ERα); estrogens; Humans; lungs; Male; metastasis; Mice; Mice, Nude; Microcystin-leucine-arginine (MC-LR); microcystin-LR; Microcystins - toxicity; migratory behavior; odds ratio; prognosis; Prostate cancer; Prostatic Neoplasms; risk; toxicity; Vimentin; xenotransplantation; China; Vimentin; Epithelial-mesenchymal transition (EMT); Prostate cancer; E-cadherin; Microcystin-leucine-arginine (MC-LR); Estrogen receptor-α (ERα)

Microcystin-leucine-arginine (MC-LR) is positively linked with multiple cancers in humans. However, the association between MC-LR and the risk and prognosis of prostate cancer has not been conducted in epidemiological studies. No reported studies have linked MC-LR exposure to the poor prognosis of p...