The influence of age on the pharmacokinetics of verapamil

The influence of age on the pharmacokinetics of verapamil at steady state has been studied in 74 individuals, age range 19-79 years, including healthy normotensive volunteers and patients with essential hypertension. The peak plasma concentrations (Cmax) of verapamil were significantly higher in old...

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Bibliographic Details
Published inPharmacological research Vol. 24; no. 3; p. 227
Main Authors Ahmed, J H, Meredith, P A, Elliott, H L
Format Journal Article
LanguageEnglish
Published Netherlands 01.10.1991
Subjects
Adult
Aged
Aging - metabolism
Body Weight - drug effects
Chromatography, High Pressure Liquid
Female
Half-Life
Humans
Hypertension - drug therapy
Hypertension - metabolism
Male
Middle Aged
Statistics as Topic
Verapamil - analogs & derivatives
Verapamil - blood
Verapamil - pharmacokinetics
Volunteers
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Summary:The influence of age on the pharmacokinetics of verapamil at steady state has been studied in 74 individuals, age range 19-79 years, including healthy normotensive volunteers and patients with essential hypertension. The peak plasma concentrations (Cmax) of verapamil were significantly higher in older subjects (r = 0.24; P = 0.03) and there was a non-significant age-related decrease in clearance/F and a non-significant increase in elimination half-life. These results suggest that increasing age is associated with changes in the pharmacokinetics of verapamil but these changes are small and unlikely to be of clinical significance.
ISSN:1043-6618
DOI:10.1016/1043-6618(91)90085-C