Glomerular basement membrane as a compressible ultrafilter

The ultrafiltration properties of isolated glomerular basement membrane were studied in vitro by forming membrane fragments into thin films for use as ultrafiltration membranes. The filtration properties of the films were examined using cytochrome c, myoglobin, lysozyme, ovalbumin, lactoglobulin, an...

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Published inMicrovascular research Vol. 38; no. 1; pp. 36 - 48
Main Authors Robinson, Garth B., Walton, Heather A.
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Inc 01.07.1989
Elsevier
Subjects
Animals
Artificial membranes and reconstituted systems
Basement Membrane - physiology
Biological and medical sciences
Capillaries - physiology
Capillary Permeability
Elasticity
Fundamental and applied biological sciences. Psychology
In Vitro Techniques
Kidney Glomerulus - blood supply
Kidney Glomerulus - physiology
Membrane physicochemistry
Molecular biophysics
Proteins - metabolism
Swine
Ultrafiltration
Glomerular filtration
Artificial membrane
In vitro
Kidney
Basement membrane
Pig
Proteins
Vertebrata
Mammalia
Ultrafiltration
Urinary system
Artiodactyla
Ungulata
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Summary:The ultrafiltration properties of isolated glomerular basement membrane were studied in vitro by forming membrane fragments into thin films for use as ultrafiltration membranes. The filtration properties of the films were examined using cytochrome c, myoglobin, lysozyme, ovalbumin, lactoglobulin, and serum albumin. The films behaved as compressible filters showing size-dependent rejection of the proteins. The behavior of the films was modelled using the fiber matrix hypothesis which gave good prediction of film behavior. The membrane behaved as a random fiber matrix composed of fibers of 0.8–1.0 nm in radius.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0026-2862
1095-9319
DOI:10.1016/0026-2862(89)90015-0