Signaling by Type I Interferons in Immune Cells: Disease Consequences

This review addresses interferon (IFN) signaling in immune cells and the tumor microenvironment (TME) and examines how this affects cancer progression. The data reveal that IFNs exert dual roles in cancers, dependent on the TME, exhibiting both anti-tumor activity and promoting cancer progression. W...

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Bibliographic Details
Published inCancers Vol. 16; no. 8; p. 1600
Main Authors Zannikou, Markella, Fish, Eleanor N, Platanias, Leonidas C
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 22.04.2024
Subjects
Antigens
Antitumor agents
cancer
Cancer therapies
Cell growth
Cell proliferation
Cell surface
Cytotoxicity
dendritic cell
DNA damage
Gene expression
immune cells
Immune response
Immune system
Interferon
interferons
Kinases
Lymphocytes
macrophage
Metabolism
Neutrophils
Proteins
signaling
Tumor microenvironment
Tumors
Viruses
NK cells
interferons
signaling
T cell
immune cells
macrophage
cancer
B cells
tumor microenvironment
neutrophils
dendritic cell
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Summary:This review addresses interferon (IFN) signaling in immune cells and the tumor microenvironment (TME) and examines how this affects cancer progression. The data reveal that IFNs exert dual roles in cancers, dependent on the TME, exhibiting both anti-tumor activity and promoting cancer progression. We discuss the abnormal IFN signaling induced by cancerous cells that alters immune responses to permit their survival and proliferation.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers16081600