Facilitating effects of deep brain stimulation on feedback learning in Parkinson’s disease

• Published in: Behavioural brain research Vol. 313; pp. 88 - 96
• Main Authors: Meissner, Sarah Nadine, Südmeyer, Martin, Keitel, Ariane, Pollok, Bettina, Bellebaum, Christian
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.10.2016
• Subjects: Active feedback learning; Cognition; Deep Brain Stimulation; Female; Formative Feedback; Humans; Male; Middle Aged; Observation; Parkinson Disease - psychology; Parkinson Disease - therapy; Parkinson’s disease; Subthalamic Nucleus - physiopathology; Observation; Cognition; Deep brain stimulation; Active feedback learning; Parkinson’s disease
• ISSN: 0166-4328; 1872-7549
• DOI: 10.1016/j.bbr.2016.06.062

•STN-DBS improves active feedback learning in PD patients.•In the absence of trial-by-trial feedback, more impaired patients benefit from DBS.•STN-DBS tends to improve observational feedback learning.•STN-DBS might similarly affect active and observational feedback learning. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) provides an effective treatment for Parkinson’s disease (PD) motor symptoms. However, findings of effects on cognitive function such as feedback learning remain controversial and rare. The aim of the present study was to gain a better understanding of cognitive alterations associated with STN-DBS. Therefore, we investigated effects of STN-DBS on active and observational feedback learning in PD. 18 PD patients with STN-DBS and 18 matched healthy controls completed active and observational feedback learning tasks. Patients were investigated ON and OFF STN-DBS. Tasks consisted of learning (with feedback) and test phases (without feedback). STN-DBS improved active learning during feedback trials and PD patients ON (but not OFF) STN-DBS showed comparable performance patterns as healthy controls. No STN-DBS effect was found when assessing performance during active test trials without feedback. In this case, however, STN-DBS effects were found to depend on symptom severity. While more impaired patients benefited from STN-DBS, stimulation had no facilitating effect on patients with less severe symptoms. Along similar lines, the severity of motor symptoms tended to be significantly correlated with differences in active test performance due to STN-DBS. For observational feedback learning, there was a tendency for a positive STN-DBS effect with patients reaching the performance level of healthy controls only ON STN-DBS. The present data suggest that STN-DBS facilitates active feedback learning in PD patients. Furthermore, they provide first evidence that STN-DBS might not only affect learning from own but also from observed actions and outcomes.