Functional tolerance to alprazolam-induced neurologic deficits in mice

Tolerance to alprazolam-induced neurologic deficits was assessed in mice by a rotarod test. Tolerance was found following a second administration of 2 mg/kg alprazolam 24 h after the first dose and it decayed gradually over a period of several weeks. Brain and plasma concentrations of alprazolam ind...

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Bibliographic Details
Published inLife sciences (1973) Vol. 35; no. 20; p. 2065
Main Authors Henauer, S A, Lombrozo, L, Hollister, L E
Format Journal Article
LanguageEnglish
Published Netherlands 12.11.1984
Subjects
Alprazolam
Animals
Benzodiazepines - metabolism
Benzodiazepines - toxicity
Brain - drug effects
Drug Tolerance
Hypnotics and Sedatives - toxicity
Male
Mice
Motor Activity - drug effects
Nervous System - drug effects
Nervous System - physiopathology
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Summary:Tolerance to alprazolam-induced neurologic deficits was assessed in mice by a rotarod test. Tolerance was found following a second administration of 2 mg/kg alprazolam 24 h after the first dose and it decayed gradually over a period of several weeks. Brain and plasma concentrations of alprazolam indicated that this tolerance was functional.
ISSN:0024-3205
1879-0631
DOI:10.1016/0024-3205(84)90564-2