Recent developments in liquid chromatography–mass spectrometry and related techniques

► Comprehensive list of current LC–MS and MALDI-TOF instrumentation. ► Overview of current trends in LC–MS. ► MS approaches complementary to LC–MS. This review summarizes the state-of-art in liquid chromatography–mass spectrometry (LC–MS) and related techniques with the main focus on recent developm...

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Published inJournal of Chromatography A Vol. 1259; pp. 3 - 15
Main Authors Holčapek, Michal, Jirásko, Robert, Lísa, Miroslav
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 12.10.2012
Subjects
analytical chemistry
Animals
Blood Proteins - analysis
Chromatography, Liquid - methods
desorption
Fast LC
Humans
ionization
LC–MS
liquid chromatography
Mass accuracy
Mass spectrometry
Mass Spectrometry - methods
Proteome - analysis
Proteomics
Resolving power
spectrometers
UHPLC
Resolving power
UHPLC
Mass accuracy
Mass spectrometry
LC–MS
Fast LC
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Summary:► Comprehensive list of current LC–MS and MALDI-TOF instrumentation. ► Overview of current trends in LC–MS. ► MS approaches complementary to LC–MS. This review summarizes the state-of-art in liquid chromatography–mass spectrometry (LC–MS) and related techniques with the main focus on recent developments in the last decade. LC–MS records an enormous growth in recent years due to the application potential in analytical chemistry, biochemistry, pharmaceutical analysis, clinical analysis and many other fields, where the qualitative and quantitative characterization of complex organic, bioorganic and organometallic mixtures is needed. Beginners and moderately experienced LC–MS users may be confused by the number of different LC–MS systems on the market, therefore an actual overview of mass spectrometers designed for the LC–MS configuration and matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) from main manufacturers is compiled here together with an independent assessment of their advantages and limitations. Current trends in terms of mass analyzers, ionization techniques, fast LC–MS, LC–MALDI-MS, ion mobility spectrometry used in LC–MS, quantitation issues specific to MS and emerging mass spectrometric approaches complementary to LC–MS are discussed as well.
Bibliography:http://dx.doi.org/10.1016/j.chroma.2012.08.072
ISSN:0021-9673
1873-3778
DOI:10.1016/j.chroma.2012.08.072