Bradykinin level in the great cardiac vein during balloon angioplasty of the left anterior descending coronary artery

• Published in: The American journal of cardiology Vol. 70; no. 20; pp. 1621 - 1623
• Main Authors: Eldar, Michael, Hollander, Gerald, Schulhoff, Nancy, Ohlstein, Elliot, Greengart, Alvin, Lichstein, Edgar, Shani, Jacob
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.12.1992; Elsevier
• Subjects: Aged; Angina Pectoris - blood; Angina Pectoris - physiopathology; Angina Pectoris - therapy; Angioplasty, Balloon, Coronary; Biological and medical sciences; Bradykinin - blood; Bradykinin - physiology; Coronary Vessels; Diseases of the cardiovascular system; Female; Humans; Male; Medical sciences; Myocardial Ischemia - etiology; Myocardial Ischemia - physiopathology; Nociceptors - physiology; Pain Measurement; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Thromboxane B2 - blood; Human; Biochemical analysis; Coronary vein; Etiopathogenesis; Cuffed tube; Instrumentation therapy; Cardiovascular disease; Instrumental dilatation; Angina pectoris; Coronary heart disease; Blood plasma; Pain; Bradykinin; Anterior intraventricular artery
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/0002-9149(92)90472-B

Chest pain is one of the hallmarks of myocardial ischemia (angina pectoris). Exact mechanisms responsible for the production of ischemia-induced pain are not clear. 1 A prevailing hypothesis postulates the activation of peripheral nociceptive receptors by substances originating in the ischemic myocardium. 2–4 Several investigators have suggested that bradykinin, one of the most potent natural algesic substances, may be responsible for anginal pain. 5,6 Kimura et al 7 found that coronary ligation in the dog induces a rapid increase in the coronary sinus level of bradykinin. The relation of bradykmin to myocardial ischemic pain in humans has not been previously reported. We studied the plasma bradykinin level in the great cardiac vein during transient myocardial ischemia induced by balloon angioplasty of the left anterior descending coronary artery in humans.