Evidence for a universal process underlying clonal attenuation

It is shown by computer simulation that an established commitment model of clonal attenuation can account for clone size distribution data obtained from three vertebrate species — chick, hamster and human — from two evolutionarily divergent classes. The different in vitro replicative lifespans of ea...

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Bibliographic Details
Published inMechanisms of ageing and development Vol. 38; no. 3; pp. 267 - 276
Main Authors Angello, John C., Prothero, John W.
Format Journal Article
LanguageEnglish
Published Shannon Elsevier Ireland Ltd 01.05.1987
Elsevier Science
Subjects
Animals
Biological and medical sciences
Cell cultures. Hybridization. Fusion
Cell Cycle
Cell Division
Chick
Chick Embryo
Clone Cells - cytology
Commitment
Computer Simulation
Cricetinae
Fibroblasts
Fibroblasts - cytology
Fundamental and applied biological sciences. Psychology
General aspects
Hamster
Human
Humans
Molecular and cellular biology
Probability
Time Factors
Human
Fibroblasts
Model
Probability
Commitment
Chick
Hamster
Cell cloning
Cell culture
Vertebrata
Regulation(control)
Mammalia
Computer simulation
Interspecific comparison
Models
Fibroblast
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Summary:It is shown by computer simulation that an established commitment model of clonal attenuation can account for clone size distribution data obtained from three vertebrate species — chick, hamster and human — from two evolutionarily divergent classes. The different in vitro replicative lifespans of each cell strain can be explained simply by differences in cell kinetics. These results suggest that the process of clonal attenuation is qualitatively similar in fibroblasts from all vertebrate species.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0047-6374
1872-6216
DOI:10.1016/0047-6374(87)90095-9