Epidermal growth factor receptor family tyrosine kinases as signal integrators and therapeutic targets

Activating mutations, gene amplification and overexpression of human epidermal growth factor receptor (erbB or HER) family kinases have been implicated as integral contributors to a variety of cancers. However, there is increasing evidence that the HER family receptors propagate not only signals ini...

Full description

Saved in:
Bibliographic Details
Published inCancer and metastasis reviews Vol. 22; no. 4; pp. 301 - 307
Main Authors Barnes, Christopher J., Kumar, Rakesh
Format Journal Article
LanguageEnglish
Published Netherlands Springer Nature B.V 01.12.2003
Subjects
Humans
Neoplasms - metabolism
Neoplasms - therapy
Receptor, Epidermal Growth Factor - metabolism
Receptor, Epidermal Growth Factor - physiology
Receptors, Estrogen
Signal Transduction
Transcriptional Activation
Vascular Endothelial Growth Factor A - metabolism
Online AccessGet full text

Cover

More Information
Summary:Activating mutations, gene amplification and overexpression of human epidermal growth factor receptor (erbB or HER) family kinases have been implicated as integral contributors to a variety of cancers. However, there is increasing evidence that the HER family receptors propagate not only signals initiated by their own ligands but also those initiated by multiple other signaling pathways. Attenuation of HER family signaling is a developing strategy for the management of human malignancies and is the subject of a number of ongoing clinical trials. The purpose of this review is to provide a timely update of recent reports in the rapidly evolving area of HER family biology and the emerging integral role of these receptors in malignant transformation and as targets of cancer therapy.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:0167-7659
1573-7233
DOI:10.1023/A:1023726827771