Effect of androgens on phalloidin-induced liver toxicity in mice

A single i.p. dose of phalloidin, 0.75 or 1 mg/kg body weight, induced peliosis hepatis-like lesion (PHLL) at 3 h after injection to mice. Pretreatment with various doses of testosterone propionate for 7 days enhanced phalloidin-induced PHLL. Other anabolic steroids, methyltestosterone, methandriol....

Full description

Saved in:
Bibliographic Details
Published inToxicology letters Vol. 40; no. 3; p. 203
Main Authors Muraoka, Y, Watanabe, H, Kometani, M, Hasegawa, T
Format Journal Article
LanguageEnglish
Published Netherlands 01.03.1988
Subjects
Androgens - toxicity
Animals
Chemical and Drug Induced Liver Injury - etiology
Drug Synergism
Female
Liver - drug effects
Mice
Mice, Inbred C3H
Oligopeptides - toxicity
Phalloidine - toxicity
Testosterone - toxicity
Online AccessGet more information

Cover

More Information
Summary:A single i.p. dose of phalloidin, 0.75 or 1 mg/kg body weight, induced peliosis hepatis-like lesion (PHLL) at 3 h after injection to mice. Pretreatment with various doses of testosterone propionate for 7 days enhanced phalloidin-induced PHLL. Other anabolic steroids, methyltestosterone, methandriol. fluoxymesterone and oxymetholone had no effect.
ISSN:0378-4274
DOI:10.1016/0378-4274(88)90042-2